My take go for the one your most likely to win

If she if rated highly in the handicap and will land at the top of the weights she may struggle, most do. The grade race will be a significantly greater challenge period but at some point he rating will force you in this direction anyway and it is the only way to know.
Final thing look at next week, Cheltenham, is there a race there you want her for and or is there maybe a easy graded option as all the monster will be in the G1's?
Is how I would look at it
Josh